Recent advances in the molecular mechanism of thalidomide teratogenicity
نویسندگان
چکیده
منابع مشابه
Evidence for the intercalation of thalidomide into DNA: clue to the molecular mechanism of thalidomide teratogenicity?
The intercalation of thalidomide (alpha-phthalimidoglutarimide) into nucleic acids was studied by spectrophotometric titrations, displacement of known intercalators, viscosity changes of DNA solutions, and by phase partition analysis. Specific binding of thalidomide was found to DNA of various specimens (human placenta, calf thymus, salmon sperm), but not to RNA (from bakers yeast, torula yeast).
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Nitric oxide rescues thalidomide mediated teratogenicity
Thalidomide, a sedative drug given to pregnant women, unfortunately caused limb deformities in thousands of babies. Recently the drug was revived because of its therapeutic potential; however the search is still ongoing for an antidote against thalidomide induced limb deformities. In the current study we found that nitric oxide (NO) rescues thalidomide affected chick (Gallus gallus) and zebrafi...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2020
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2020.110114